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KMID : 0377619960610090683
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Korean Jungang Medical Journal
1996 Volume.61 No. 9 p.683 ~ p.684
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Trial of Screening for Ovarian Cancer Using Tumor Markers (CA602 and CA546)
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Nozawa, Shiro
Udagawa, Yasuhiro
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Abstract
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Objective:
Screening for ovarian cancer has not yet been realized because of the relatively low morbidity and difficulty in identifying the high - risk group of this disease. However, taking into consideration the increase in morbidity in recent years and the economic benefits of early detection and treatment, ovarian cancer seems to be a disease worthy of development of a screening technique. At present, examinations using a transvaginal probe or tumor markers are being evaluated for their potential use. We carried out a prospective study on the usefulness of tumor markers in screening for ovarian cancer.
Method:
The subjects of this study were women who were examined in the gynecology departments of 53 institutions, including cancer screening centers, in Japan during an 18 - month period beginning in February 1994. A combination assay using CA602(an analogous antigen to Ca125) and Ca546(a mucin - type glycoprotein), which have mutual supplementary properties, was applied. Patients found positive with this assay were examined for ´ the presence or absence of an ovarian tumor by echography. Those with positive findings were then subjected to MRI examination and a surgical procedure to detect ovarian cancer.
Results:
A total of 21,464 women were subjected to our combination tumor marker assay. Of these patients, 2,829 patients(13.2 %) were positive for the markers according to the conventional cut - off level, and 2,124 patients(75 %) of these underwant echography. Ovarian tumors were detected in 543 patients. The surgical procedure detected ovarian cancer in six patients, about 0.04 % of women. This rate is consistent with .the morbidity rate of ovarian cancer. Of 6 patients with ovarian cancer, 3 were positive for both markers and 3 were positive for CA602 alone.
Conclusion:
The results of this study show that the use of tumor markers is useful for screening of
high - risk group for ovarian cancer. The benefits of this technique include simple collection
of specimens. possibility of objective judgment and feasibility of the test even in women who receive non-gynecologic examinations as well as unmarried or young women.
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KEYWORD
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